White matter lesion progression: A genome-wide search for genetic influences
Identifieur interne : 002640 ( Main/Exploration ); précédent : 002639; suivant : 002641White matter lesion progression: A genome-wide search for genetic influences
Auteurs : Edith Hofer [Autriche] ; Margherita Cavalieri [Autriche] ; Joshua C. Bis [États-Unis] ; Charles Decarli [États-Unis] ; Myriam Fornage [États-Unis] ; Sigurdur Sigurdsson [Islande] ; Velandai Srikanth [Australie] ; Stella Trompet [Pays-Bas] ; Benjamin Fj Verhaaren [Pays-Bas] ; Christiane Wolf [France, Allemagne] ; Qiong Yang [États-Unis] ; Hieab Hh Adams [Pays-Bas] ; Philippe Amouyel [France] ; Alexa Beiser [États-Unis] ; Brendan M. Buckley [Irlande (pays)] ; Michele Callisaya [Australie] ; Ganesh Chauhan [France] ; Anton Jm De Craen [Pays-Bas] ; Carole Dufouil [France] ; Cornelia M. Van Duijn [Pays-Bas] ; Ian Ford [Royaume-Uni] ; Paul Freudenberger [Autriche] ; Rebecca F. Gottesman [États-Unis] ; Vilmundur Gudnason [Islande] ; Gerardo Heiss [États-Unis] ; Albert Hofman [Pays-Bas] ; Thomas Lumley [Nouvelle-Zélande] ; Oliver Martinez [États-Unis] ; Bernard Mazoyer [France] ; Chris Moran [Australie] ; Wiro J. Niessen [Pays-Bas] ; Thanh Phan [Australie] ; Bruce M. Psaty [États-Unis] ; Claudia L. Satizabal [États-Unis] ; Naveed Sattar [Royaume-Uni] ; Sabrina Schilling [France] ; Dean K. Shibata [États-Unis] ; P Eline Slagboom [Pays-Bas] ; Albert Smith [Islande] ; David J. Stott [Royaume-Uni] ; Kent D. Taylor [États-Unis] ; Russell Thomson [Australie] ; Anna M. Töglhofer [Autriche] ; Christophe Tzourio [France] ; Mark Van Buchem [Pays-Bas] ; Jing Wang [États-Unis] ; Rudi Gj Westendorp [Pays-Bas, Danemark] ; B Gwen Windham [États-Unis] ; Meike W. Vernooij [Pays-Bas] ; Alex Zijdenbos [Canada] ; Richard Beare [Australie] ; Stéphanie Debette [France, États-Unis] ; M Arfan Ikram [Pays-Bas] ; J Wouter Jukema [Pays-Bas] ; Lenore J. Launer [États-Unis] ; W T Longstreth [États-Unis] ; Thomas H. Mosley [États-Unis] ; Sudha Seshadri [États-Unis] ; Helena Schmidt [Autriche] ; Reinhold Schmidt [Autriche]Source :
- Stroke; a journal of cerebral circulation [ 0039-2499 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Femelle, Humains, Leucoencéphalopathies (diagnostic), Leucoencéphalopathies (génétique), Leucoencéphalopathies (épidémiologie), Mâle, Prédisposition génétique à une maladie (génétique), Prédisposition génétique à une maladie (épidémiologie), Substance blanche (anatomopathologie), Sujet âgé, Étude d'association pangénomique (), Études de cohortes, Études prospectives, Évolution de la maladie.
- MESH :
- anatomopathologie : Substance blanche.
- diagnostic : Leucoencéphalopathies.
- génétique : Leucoencéphalopathies, Prédisposition génétique à une maladie.
- épidémiologie : Leucoencéphalopathies, Prédisposition génétique à une maladie.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Mâle, Sujet âgé, Étude d'association pangénomique, Études de cohortes, Études prospectives, Évolution de la maladie.
English descriptors
- KwdEn :
- Adult, Aged, Cohort Studies, Disease Progression, Female, Genetic Predisposition to Disease (epidemiology), Genetic Predisposition to Disease (genetics), Genome-Wide Association Study (methods), Humans, Leukoencephalopathies (diagnosis), Leukoencephalopathies (epidemiology), Leukoencephalopathies (genetics), Male, Middle Aged, Prospective Studies, White Matter (pathology).
- MESH :
- diagnosis : Leukoencephalopathies.
- epidemiology : Genetic Predisposition to Disease, Leukoencephalopathies.
- genetics : Genetic Predisposition to Disease, Leukoencephalopathies.
- methods : Genome-Wide Association Study.
- pathology : White Matter.
- Adult, Aged, Cohort Studies, Disease Progression, Female, Humans, Male, Middle Aged, Prospective Studies.
Abstract
White matter lesion (WML) progression on magnetic resonance imaging (MRI) is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants associated with WML progression in elderly participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
Heritability of WML progression was calculated in the Framingham Heart Study. The genome-wide association study included 7773 elderly participants from 10 cohorts. To assess the relative contribution of genetic factors to progression of WML, we compared in seven cohorts risk models including demographics, vascular risk factors plus single nucleotide polymorphisms (SNPs) that have been shown to be associated cross-sectionally with WML in the current and previous association studies.
A total of 1085 subjects showed WML progression. The heritability estimate for WML progression was low at 6.5%, and no SNPs achieved genome-wide significance (p-value < 5×10−8). Four loci were suggestive (p-value < 1×10−5) of an association with WML progression: 10q24.32 (rs10883817, p=1.46×10−6); 12q13.13 (rs4761974, p=8.71×10−7); 20p12.1 (rs6135309, p=3.69×10−6); and 4p15.31 (rs7664442, p=2.26×10−6). Variants that have been previously related to WML explained only 0.8% to 11.7% more of the variance in WML progression than age, vascular risk factors and baseline WML burden.
Common genetic factors contribute little to the progression of age-related WML in middle-aged and older adults. Future research on determinants of WML progression should focus more on environmental, life-style or host-related biological factors.
Url:
DOI: 10.1161/STROKEAHA.115.009252
PubMed: 26451028
PubMed Central: 4749149
Affiliations:
- Allemagne, Australie, Autriche, Canada, Danemark, France, Irlande (pays), Islande, Nouvelle-Zélande, Pays-Bas, Royaume-Uni, États-Unis
- Aquitaine, Bavière, Californie, Caroline du Nord, District de Haute-Bavière, Hauts-de-France, Hollande-Méridionale, Hollande-Septentrionale, Hovedstaden, Maryland, Massachusetts, Nord-Pas-de-Calais, Nouvelle-Aquitaine, Texas, Utrecht (province), Washington (État), Écosse, État du Mississippi, Île-de-France
- Amsterdam, Bordeaux, Copenhague, Glasgow, Leyde, Lille, Munich, Paris, Rotterdam, Seattle, Utrecht
- Université Bordeaux II, Université de Glasgow, Université de Washington
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Le document en format XML
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of Statistical Genetics, Max Planck Institute of Psychiatry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><affiliation wicri:level="2"><nlm:aff id="A15">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Adams, Hieab Hh" sort="Adams, Hieab Hh" uniqKey="Adams H" first="Hieab Hh" last="Adams">Hieab Hh Adams</name><affiliation wicri:level="3"><nlm:aff id="A11">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A12">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="3"><nlm:aff id="A16">INSERM U744, Pasteur Institute, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U744, Pasteur Institute, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><affiliation wicri:level="2"><nlm:aff id="A15">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M" last="Buckley">Brendan M. Buckley</name><affiliation wicri:level="1"><nlm:aff id="A17">Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Pharmacology and Therapeutics, University College Cork, Cork</wicri:regionArea><wicri:noRegion>Cork</wicri:noRegion></affiliation></author><author><name sortKey="Callisaya, Michele" sort="Callisaya, Michele" uniqKey="Callisaya M" first="Michele" last="Callisaya">Michele Callisaya</name><affiliation wicri:level="1"><nlm:aff id="A8">Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Chauhan, Ganesh" sort="Chauhan, Ganesh" uniqKey="Chauhan G" first="Ganesh" last="Chauhan">Ganesh Chauhan</name><affiliation wicri:level="4"><nlm:aff id="A13">INSERM U897, Université Bordeaux Segalen, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U897, Université Bordeaux Segalen, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université Bordeaux II</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A18">INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="De Craen, Anton Jm" sort="De Craen, Anton Jm" uniqKey="De Craen A" first="Anton Jm" last="De Craen">Anton Jm De Craen</name><affiliation wicri:level="3"><nlm:aff id="A10">Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><affiliation wicri:level="4"><nlm:aff id="A13">INSERM U897, Université Bordeaux Segalen, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U897, Université Bordeaux Segalen, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université Bordeaux II</orgName></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="3"><nlm:aff id="A11">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A19">Centre for Medical Systems Biology, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Centre for Medical Systems Biology, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation wicri:level="4"><nlm:aff id="A20">Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Robertson Center for Biostatistics, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Freudenberger, Paul" sort="Freudenberger, Paul" uniqKey="Freudenberger P" first="Paul" last="Freudenberger">Paul Freudenberger</name><affiliation wicri:level="1"><nlm:aff id="A21">Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Gottesman, Rebecca F" sort="Gottesman, Rebecca F" uniqKey="Gottesman R" first="Rebecca F" last="Gottesman">Rebecca F. Gottesman</name><affiliation wicri:level="2"><nlm:aff id="A22">Department of Neurology, Johns Hopkins University, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="A7">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A23">University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Heiss, Gerardo" sort="Heiss, Gerardo" uniqKey="Heiss G" first="Gerardo" last="Heiss">Gerardo Heiss</name><affiliation wicri:level="2"><nlm:aff id="A24">Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of North Carolina, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:aff id="A11">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Lumley, Thomas" sort="Lumley, Thomas" uniqKey="Lumley T" first="Thomas" last="Lumley">Thomas Lumley</name><affiliation wicri:level="1"><nlm:aff id="A25">Department of Statistics, University of Auckland, Auckland, New Zealand</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Statistics, University of Auckland, Auckland</wicri:regionArea><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="Martinez, Oliver" sort="Martinez, Oliver" uniqKey="Martinez O" first="Oliver" last="Martinez">Oliver Martinez</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name><affiliation wicri:level="4"><nlm:aff id="A26">CNRS-CEA UMR5296, Université Bordeaux Segalen, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS-CEA UMR5296, Université Bordeaux Segalen, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université Bordeaux II</orgName></affiliation></author><author><name sortKey="Moran, Chris" sort="Moran, Chris" uniqKey="Moran C" first="Chris" last="Moran">Chris Moran</name><affiliation wicri:level="1"><nlm:aff id="A8">Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name><affiliation wicri:level="3"><nlm:aff id="A27">Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Informatics, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A28">Faculty of Applied Sciences, Delft University, Delft, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Faculty of Applied Sciences, Delft University, Delft</wicri:regionArea><wicri:noRegion>Delft</wicri:noRegion></affiliation></author><author><name sortKey="Phan, Thanh" sort="Phan, Thanh" uniqKey="Phan T" first="Thanh" last="Phan">Thanh Phan</name><affiliation wicri:level="1"><nlm:aff id="A8">Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation wicri:level="4"><nlm:aff id="A3">Cardiovascular Health Research Unit, Departments of Medicine, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Departments of Medicine, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="2"><nlm:aff id="A29">Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute, Group Health Cooperative, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Satizabal, Claudia L" sort="Satizabal, Claudia L" uniqKey="Satizabal C" first="Claudia L" last="Satizabal">Claudia L. Satizabal</name><affiliation wicri:level="2"><nlm:aff id="A30">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><affiliation wicri:level="1"><nlm:aff id="A31">Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, Glasgow, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Schilling, Sabrina" sort="Schilling, Sabrina" uniqKey="Schilling S" first="Sabrina" last="Schilling">Sabrina Schilling</name><affiliation wicri:level="4"><nlm:aff id="A13">INSERM U897, Université Bordeaux Segalen, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U897, Université Bordeaux Segalen, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université Bordeaux II</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A18">INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Shibata, Dean K" sort="Shibata, Dean K" uniqKey="Shibata D" first="Dean K" last="Shibata">Dean K. Shibata</name><affiliation wicri:level="4"><nlm:aff id="A32">Department of Radiology, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Slagboom, P Eline" sort="Slagboom, P Eline" uniqKey="Slagboom P" first="P Eline" last="Slagboom">P Eline Slagboom</name><affiliation wicri:level="3"><nlm:aff id="A33">Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Molecular Epidemiology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Smith, Albert" sort="Smith, Albert" uniqKey="Smith A" first="Albert" last="Smith">Albert Smith</name><affiliation wicri:level="1"><nlm:aff id="A7">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A23">University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J" last="Stott">David J. Stott</name><affiliation wicri:level="1"><nlm:aff id="A31">Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, Glasgow, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D" last="Taylor">Kent D. Taylor</name><affiliation wicri:level="2"><nlm:aff id="A34">Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A35">Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name><affiliation wicri:level="1"><nlm:aff id="A36">Menzies Research Institute, Hobart, Tasmania, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Research Institute, Hobart, Tasmania</wicri:regionArea><wicri:noRegion>Tasmania</wicri:noRegion></affiliation></author><author><name sortKey="Toglhofer, Anna M" sort="Toglhofer, Anna M" uniqKey="Toglhofer A" first="Anna M" last="Töglhofer">Anna M. Töglhofer</name><affiliation wicri:level="1"><nlm:aff id="A21">Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="4"><nlm:aff id="A37">INSERM U708, Université Bordeaux Segalen, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U708, Université Bordeaux Segalen, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université Bordeaux II</orgName></affiliation></author><author><name sortKey="Van Buchem, Mark" sort="Van Buchem, Mark" uniqKey="Van Buchem M" first="Mark" last="Van Buchem">Mark Van Buchem</name><affiliation wicri:level="3"><nlm:aff id="A38">Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name><affiliation wicri:level="2"><nlm:aff id="A15">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Westendorp, Rudi Gj" sort="Westendorp, Rudi Gj" uniqKey="Westendorp R" first="Rudi Gj" last="Westendorp">Rudi Gj Westendorp</name><affiliation wicri:level="3"><nlm:aff id="A10">Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A39">Department of Public Health, University of Copenhagen, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Public Health, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Windham, B Gwen" sort="Windham, B Gwen" uniqKey="Windham B" first="B Gwen" last="Windham">B Gwen Windham</name><affiliation wicri:level="2"><nlm:aff id="A40">Department of Medicine, University of Mississippi, Jackson, MS, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Mississippi, Jackson, MS</wicri:regionArea><placeName><region type="state">État du Mississippi</region></placeName></affiliation></author><author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W" last="Vernooij">Meike W. Vernooij</name><affiliation wicri:level="3"><nlm:aff id="A11">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A12">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Zijdenbos, Alex" sort="Zijdenbos, Alex" uniqKey="Zijdenbos A" first="Alex" last="Zijdenbos">Alex Zijdenbos</name><affiliation wicri:level="1"><nlm:aff id="A41">Biospective Inc., Montréal, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Biospective Inc., Montréal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Beare, Richard" sort="Beare, Richard" uniqKey="Beare R" first="Richard" last="Beare">Richard Beare</name><affiliation wicri:level="1"><nlm:aff id="A8">Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A42">Developmental Imaging, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Developmental Imaging, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stéphanie" last="Debette">Stéphanie Debette</name><affiliation wicri:level="4"><nlm:aff id="A13">INSERM U897, Université Bordeaux Segalen, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U897, Université Bordeaux Segalen, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université Bordeaux II</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A18">INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A30">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name><affiliation wicri:level="3"><nlm:aff id="A11">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A12">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name><affiliation wicri:level="3"><nlm:aff id="A9">Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A43">Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Durrer Center for Cardiogenetic Research, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A44">Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Interuniversity Cardiology Institute of the Netherlands, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation wicri:level="2"><nlm:aff id="A45">National Institute on Aging, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute on Aging, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Longstreth, W T" sort="Longstreth, W T" uniqKey="Longstreth W" first="W T" last="Longstreth">W T Longstreth</name><affiliation wicri:level="4"><nlm:aff id="A46">Departments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Epidemiology, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name><affiliation wicri:level="2"><nlm:aff id="A40">Department of Medicine, University of Mississippi, Jackson, MS, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Mississippi, Jackson, MS</wicri:regionArea><placeName><region type="state">État du Mississippi</region></placeName></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="2"><nlm:aff id="A30">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Graz, Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A21">Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Graz, Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26451028</idno><idno type="pmc">4749149</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749149</idno><idno type="RBID">PMC:4749149</idno><idno type="doi">10.1161/STROKEAHA.115.009252</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001C76</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C76</idno><idno type="wicri:Area/Pmc/Curation">001B34</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001B34</idno><idno type="wicri:Area/Pmc/Checkpoint">000C38</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C38</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002772</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002772</idno><idno type="wicri:Area/PubMed/Curation">002703</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002703</idno><idno type="wicri:Area/PubMed/Checkpoint">002703</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002703</idno><idno type="wicri:Area/Ncbi/Merge">002B98</idno><idno type="wicri:Area/Ncbi/Curation">002B98</idno><idno type="wicri:Area/Ncbi/Checkpoint">002B98</idno><idno type="wicri:doubleKey">0039-2499:2015:Hofer E:white:matter:lesion</idno><idno type="wicri:Area/Main/Merge">002639</idno><idno type="wicri:Area/Main/Curation">002640</idno><idno type="wicri:Area/Main/Exploration">002640</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">White matter lesion progression: A genome-wide search for genetic influences</title><author><name sortKey="Hofer, Edith" sort="Hofer, Edith" uniqKey="Hofer E" first="Edith" last="Hofer">Edith Hofer</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Graz, Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Graz, Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name><affiliation wicri:level="4"><nlm:aff id="A3">Cardiovascular Health Research Unit, Departments of Medicine, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Departments of Medicine, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation wicri:level="2"><nlm:aff id="A5">Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A6">Human Genetics Center, University of Texas Health Science Center, Houston, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Genetics Center, University of Texas Health Science Center, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Sigurdsson, Sigurdur" sort="Sigurdsson, Sigurdur" uniqKey="Sigurdsson S" first="Sigurdur" last="Sigurdsson">Sigurdur Sigurdsson</name><affiliation wicri:level="1"><nlm:aff id="A7">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation></author><author><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name><affiliation wicri:level="1"><nlm:aff id="A8">Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation wicri:level="3"><nlm:aff id="A9">Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A10">Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Verhaaren, Benjamin Fj" sort="Verhaaren, Benjamin Fj" uniqKey="Verhaaren B" first="Benjamin Fj" last="Verhaaren">Benjamin Fj Verhaaren</name><affiliation wicri:level="3"><nlm:aff id="A11">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A12">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wolf, Christiane" sort="Wolf, Christiane" uniqKey="Wolf C" first="Christiane" last="Wolf">Christiane Wolf</name><affiliation wicri:level="4"><nlm:aff id="A13">INSERM U897, Université Bordeaux Segalen, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U897, Université Bordeaux Segalen, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université Bordeaux II</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><affiliation wicri:level="2"><nlm:aff id="A15">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Adams, Hieab Hh" sort="Adams, Hieab Hh" uniqKey="Adams H" first="Hieab Hh" last="Adams">Hieab Hh Adams</name><affiliation wicri:level="3"><nlm:aff id="A11">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A12">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="3"><nlm:aff id="A16">INSERM U744, Pasteur Institute, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U744, Pasteur Institute, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><affiliation wicri:level="2"><nlm:aff id="A15">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M" last="Buckley">Brendan M. Buckley</name><affiliation wicri:level="1"><nlm:aff id="A17">Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Pharmacology and Therapeutics, University College Cork, Cork</wicri:regionArea><wicri:noRegion>Cork</wicri:noRegion></affiliation></author><author><name sortKey="Callisaya, Michele" sort="Callisaya, Michele" uniqKey="Callisaya M" first="Michele" last="Callisaya">Michele Callisaya</name><affiliation wicri:level="1"><nlm:aff id="A8">Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Chauhan, Ganesh" sort="Chauhan, Ganesh" uniqKey="Chauhan G" first="Ganesh" last="Chauhan">Ganesh Chauhan</name><affiliation wicri:level="4"><nlm:aff id="A13">INSERM U897, Université Bordeaux Segalen, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U897, Université Bordeaux Segalen, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université Bordeaux II</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A18">INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="De Craen, Anton Jm" sort="De Craen, Anton Jm" uniqKey="De Craen A" first="Anton Jm" last="De Craen">Anton Jm De Craen</name><affiliation wicri:level="3"><nlm:aff id="A10">Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><affiliation wicri:level="4"><nlm:aff id="A13">INSERM U897, Université Bordeaux Segalen, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U897, Université Bordeaux Segalen, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université Bordeaux II</orgName></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="3"><nlm:aff id="A11">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A19">Centre for Medical Systems Biology, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Centre for Medical Systems Biology, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation wicri:level="4"><nlm:aff id="A20">Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Robertson Center for Biostatistics, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Freudenberger, Paul" sort="Freudenberger, Paul" uniqKey="Freudenberger P" first="Paul" last="Freudenberger">Paul Freudenberger</name><affiliation wicri:level="1"><nlm:aff id="A21">Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Gottesman, Rebecca F" sort="Gottesman, Rebecca F" uniqKey="Gottesman R" first="Rebecca F" last="Gottesman">Rebecca F. Gottesman</name><affiliation wicri:level="2"><nlm:aff id="A22">Department of Neurology, Johns Hopkins University, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="A7">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A23">University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Heiss, Gerardo" sort="Heiss, Gerardo" uniqKey="Heiss G" first="Gerardo" last="Heiss">Gerardo Heiss</name><affiliation wicri:level="2"><nlm:aff id="A24">Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of North Carolina, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:aff id="A11">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Lumley, Thomas" sort="Lumley, Thomas" uniqKey="Lumley T" first="Thomas" last="Lumley">Thomas Lumley</name><affiliation wicri:level="1"><nlm:aff id="A25">Department of Statistics, University of Auckland, Auckland, New Zealand</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Statistics, University of Auckland, Auckland</wicri:regionArea><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="Martinez, Oliver" sort="Martinez, Oliver" uniqKey="Martinez O" first="Oliver" last="Martinez">Oliver Martinez</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name><affiliation wicri:level="4"><nlm:aff id="A26">CNRS-CEA UMR5296, Université Bordeaux Segalen, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS-CEA UMR5296, Université Bordeaux Segalen, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université Bordeaux II</orgName></affiliation></author><author><name sortKey="Moran, Chris" sort="Moran, Chris" uniqKey="Moran C" first="Chris" last="Moran">Chris Moran</name><affiliation wicri:level="1"><nlm:aff id="A8">Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name><affiliation wicri:level="3"><nlm:aff id="A27">Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Informatics, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A28">Faculty of Applied Sciences, Delft University, Delft, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Faculty of Applied Sciences, Delft University, Delft</wicri:regionArea><wicri:noRegion>Delft</wicri:noRegion></affiliation></author><author><name sortKey="Phan, Thanh" sort="Phan, Thanh" uniqKey="Phan T" first="Thanh" last="Phan">Thanh Phan</name><affiliation wicri:level="1"><nlm:aff id="A8">Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation wicri:level="4"><nlm:aff id="A3">Cardiovascular Health Research Unit, Departments of Medicine, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Departments of Medicine, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="2"><nlm:aff id="A29">Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute, Group Health Cooperative, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Satizabal, Claudia L" sort="Satizabal, Claudia L" uniqKey="Satizabal C" first="Claudia L" last="Satizabal">Claudia L. Satizabal</name><affiliation wicri:level="2"><nlm:aff id="A30">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><affiliation wicri:level="1"><nlm:aff id="A31">Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, Glasgow, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Schilling, Sabrina" sort="Schilling, Sabrina" uniqKey="Schilling S" first="Sabrina" last="Schilling">Sabrina Schilling</name><affiliation wicri:level="4"><nlm:aff id="A13">INSERM U897, Université Bordeaux Segalen, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U897, Université Bordeaux Segalen, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université Bordeaux II</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A18">INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Shibata, Dean K" sort="Shibata, Dean K" uniqKey="Shibata D" first="Dean K" last="Shibata">Dean K. Shibata</name><affiliation wicri:level="4"><nlm:aff id="A32">Department of Radiology, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Slagboom, P Eline" sort="Slagboom, P Eline" uniqKey="Slagboom P" first="P Eline" last="Slagboom">P Eline Slagboom</name><affiliation wicri:level="3"><nlm:aff id="A33">Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Molecular Epidemiology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Smith, Albert" sort="Smith, Albert" uniqKey="Smith A" first="Albert" last="Smith">Albert Smith</name><affiliation wicri:level="1"><nlm:aff id="A7">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A23">University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J" last="Stott">David J. Stott</name><affiliation wicri:level="1"><nlm:aff id="A31">Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, Glasgow, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D" last="Taylor">Kent D. Taylor</name><affiliation wicri:level="2"><nlm:aff id="A34">Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A35">Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name><affiliation wicri:level="1"><nlm:aff id="A36">Menzies Research Institute, Hobart, Tasmania, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Research Institute, Hobart, Tasmania</wicri:regionArea><wicri:noRegion>Tasmania</wicri:noRegion></affiliation></author><author><name sortKey="Toglhofer, Anna M" sort="Toglhofer, Anna M" uniqKey="Toglhofer A" first="Anna M" last="Töglhofer">Anna M. Töglhofer</name><affiliation wicri:level="1"><nlm:aff id="A21">Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="4"><nlm:aff id="A37">INSERM U708, Université Bordeaux Segalen, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U708, Université Bordeaux Segalen, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université Bordeaux II</orgName></affiliation></author><author><name sortKey="Van Buchem, Mark" sort="Van Buchem, Mark" uniqKey="Van Buchem M" first="Mark" last="Van Buchem">Mark Van Buchem</name><affiliation wicri:level="3"><nlm:aff id="A38">Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name><affiliation wicri:level="2"><nlm:aff id="A15">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Westendorp, Rudi Gj" sort="Westendorp, Rudi Gj" uniqKey="Westendorp R" first="Rudi Gj" last="Westendorp">Rudi Gj Westendorp</name><affiliation wicri:level="3"><nlm:aff id="A10">Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A39">Department of Public Health, University of Copenhagen, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Public Health, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Windham, B Gwen" sort="Windham, B Gwen" uniqKey="Windham B" first="B Gwen" last="Windham">B Gwen Windham</name><affiliation wicri:level="2"><nlm:aff id="A40">Department of Medicine, University of Mississippi, Jackson, MS, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Mississippi, Jackson, MS</wicri:regionArea><placeName><region type="state">État du Mississippi</region></placeName></affiliation></author><author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W" last="Vernooij">Meike W. Vernooij</name><affiliation wicri:level="3"><nlm:aff id="A11">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A12">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Zijdenbos, Alex" sort="Zijdenbos, Alex" uniqKey="Zijdenbos A" first="Alex" last="Zijdenbos">Alex Zijdenbos</name><affiliation wicri:level="1"><nlm:aff id="A41">Biospective Inc., Montréal, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Biospective Inc., Montréal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Beare, Richard" sort="Beare, Richard" uniqKey="Beare R" first="Richard" last="Beare">Richard Beare</name><affiliation wicri:level="1"><nlm:aff id="A8">Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A42">Developmental Imaging, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Developmental Imaging, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stéphanie" last="Debette">Stéphanie Debette</name><affiliation wicri:level="4"><nlm:aff id="A13">INSERM U897, Université Bordeaux Segalen, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U897, Université Bordeaux Segalen, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université Bordeaux II</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A18">INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A30">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name><affiliation wicri:level="3"><nlm:aff id="A11">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A12">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name><affiliation wicri:level="3"><nlm:aff id="A9">Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A43">Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Durrer Center for Cardiogenetic Research, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A44">Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Interuniversity Cardiology Institute of the Netherlands, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation wicri:level="2"><nlm:aff id="A45">National Institute on Aging, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute on Aging, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Longstreth, W T" sort="Longstreth, W T" uniqKey="Longstreth W" first="W T" last="Longstreth">W T Longstreth</name><affiliation wicri:level="4"><nlm:aff id="A46">Departments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Epidemiology, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name><affiliation wicri:level="2"><nlm:aff id="A40">Department of Medicine, University of Mississippi, Jackson, MS, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Mississippi, Jackson, MS</wicri:regionArea><placeName><region type="state">État du Mississippi</region></placeName></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="2"><nlm:aff id="A30">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Graz, Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A21">Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Graz, Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author></analytic><series><title level="j">Stroke; a journal of cerebral circulation</title><idno type="ISSN">0039-2499</idno><idno type="eISSN">1524-4628</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cohort Studies</term><term>Disease Progression</term><term>Female</term><term>Genetic Predisposition to Disease (epidemiology)</term><term>Genetic Predisposition to Disease (genetics)</term><term>Genome-Wide Association Study (methods)</term><term>Humans</term><term>Leukoencephalopathies (diagnosis)</term><term>Leukoencephalopathies (epidemiology)</term><term>Leukoencephalopathies (genetics)</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>White Matter (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Leucoencéphalopathies (diagnostic)</term><term>Leucoencéphalopathies (génétique)</term><term>Leucoencéphalopathies (épidémiologie)</term><term>Mâle</term><term>Prédisposition génétique à une maladie (génétique)</term><term>Prédisposition génétique à une maladie (épidémiologie)</term><term>Substance blanche (anatomopathologie)</term><term>Sujet âgé</term><term>Étude d'association pangénomique ()</term><term>Études de cohortes</term><term>Études prospectives</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Substance blanche</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Leukoencephalopathies</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Leucoencéphalopathies</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Genetic Predisposition to Disease</term><term>Leukoencephalopathies</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Predisposition to Disease</term><term>Leukoencephalopathies</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Leucoencéphalopathies</term><term>Prédisposition génétique à une maladie</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genome-Wide Association Study</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>White Matter</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Leucoencéphalopathies</term><term>Prédisposition génétique à une maladie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cohort Studies</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Étude d'association pangénomique</term><term>Études de cohortes</term><term>Études prospectives</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background and Purpose</title><p id="P1">White matter lesion (WML) progression on magnetic resonance imaging (MRI) is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants associated with WML progression in elderly participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Heritability of WML progression was calculated in the Framingham Heart Study. The genome-wide association study included 7773 elderly participants from 10 cohorts. To assess the relative contribution of genetic factors to progression of WML, we compared in seven cohorts risk models including demographics, vascular risk factors plus single nucleotide polymorphisms (SNPs) that have been shown to be associated cross-sectionally with WML in the current and previous association studies.</p></sec><sec id="S3"><title>Results</title><p id="P3">A total of 1085 subjects showed WML progression. The heritability estimate for WML progression was low at 6.5%, and no SNPs achieved genome-wide significance (p-value < 5×10<sup>−8</sup>). Four loci were suggestive (p-value < 1×10<sup>−5</sup>) of an association with WML progression: 10q24.32 (rs10883817, p=1.46×10<sup>−6</sup>); 12q13.13 (rs4761974, p=8.71×10<sup>−7</sup>); 20p12.1 (rs6135309, p=3.69×10<sup>−6</sup>); and 4p15.31 (rs7664442, p=2.26×10<sup>−6</sup>). Variants that have been previously related to WML explained only 0.8% to 11.7% more of the variance in WML progression than age, vascular risk factors and baseline WML burden.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Common genetic factors contribute little to the progression of age-related WML in middle-aged and older adults. Future research on determinants of WML progression should focus more on environmental, life-style or host-related biological factors.</p></sec></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Canada</li><li>Danemark</li><li>France</li><li>Irlande (pays)</li><li>Islande</li><li>Nouvelle-Zélande</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Aquitaine</li><li>Bavière</li><li>Californie</li><li>Caroline du Nord</li><li>District de Haute-Bavière</li><li>Hauts-de-France</li><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li><li>Hovedstaden</li><li>Maryland</li><li>Massachusetts</li><li>Nord-Pas-de-Calais</li><li>Nouvelle-Aquitaine</li><li>Texas</li><li>Utrecht (province)</li><li>Washington (État)</li><li>Écosse</li><li>État du Mississippi</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Bordeaux</li><li>Copenhague</li><li>Glasgow</li><li>Leyde</li><li>Lille</li><li>Munich</li><li>Paris</li><li>Rotterdam</li><li>Seattle</li><li>Utrecht</li></settlement><orgName><li>Université Bordeaux II</li><li>Université de Glasgow</li><li>Université de Washington</li></orgName></list><tree><country name="Autriche"><noRegion><name sortKey="Hofer, Edith" sort="Hofer, Edith" uniqKey="Hofer E" first="Edith" last="Hofer">Edith Hofer</name></noRegion><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name><name sortKey="Freudenberger, Paul" sort="Freudenberger, Paul" uniqKey="Freudenberger P" first="Paul" last="Freudenberger">Paul Freudenberger</name><name sortKey="Hofer, Edith" sort="Hofer, Edith" uniqKey="Hofer E" first="Edith" last="Hofer">Edith Hofer</name><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><name sortKey="Toglhofer, Anna M" sort="Toglhofer, Anna M" uniqKey="Toglhofer A" first="Anna M" last="Töglhofer">Anna M. Töglhofer</name></country><country name="États-Unis"><region name="Washington (État)"><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name></region><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stéphanie" last="Debette">Stéphanie Debette</name><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><name sortKey="Gottesman, Rebecca F" sort="Gottesman, Rebecca F" uniqKey="Gottesman R" first="Rebecca F" last="Gottesman">Rebecca F. Gottesman</name><name sortKey="Heiss, Gerardo" sort="Heiss, Gerardo" uniqKey="Heiss G" first="Gerardo" last="Heiss">Gerardo Heiss</name><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><name sortKey="Longstreth, W T" sort="Longstreth, W T" uniqKey="Longstreth W" first="W T" last="Longstreth">W T Longstreth</name><name sortKey="Martinez, Oliver" sort="Martinez, Oliver" uniqKey="Martinez O" first="Oliver" last="Martinez">Oliver Martinez</name><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><name sortKey="Satizabal, Claudia L" sort="Satizabal, Claudia L" uniqKey="Satizabal C" first="Claudia L" last="Satizabal">Claudia L. Satizabal</name><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><name sortKey="Shibata, Dean K" sort="Shibata, Dean K" uniqKey="Shibata D" first="Dean K" last="Shibata">Dean K. Shibata</name><name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D" last="Taylor">Kent D. Taylor</name><name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D" last="Taylor">Kent D. Taylor</name><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name><name sortKey="Windham, B Gwen" sort="Windham, B Gwen" uniqKey="Windham B" first="B Gwen" last="Windham">B Gwen Windham</name><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name></country><country name="Islande"><noRegion><name sortKey="Sigurdsson, Sigurdur" sort="Sigurdsson, Sigurdur" uniqKey="Sigurdsson S" first="Sigurdur" last="Sigurdsson">Sigurdur Sigurdsson</name></noRegion><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><name sortKey="Smith, Albert" sort="Smith, Albert" uniqKey="Smith A" first="Albert" last="Smith">Albert Smith</name><name sortKey="Smith, Albert" sort="Smith, Albert" uniqKey="Smith A" first="Albert" last="Smith">Albert Smith</name></country><country name="Australie"><noRegion><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name></noRegion><name sortKey="Beare, Richard" sort="Beare, Richard" uniqKey="Beare R" first="Richard" last="Beare">Richard Beare</name><name sortKey="Beare, Richard" sort="Beare, Richard" uniqKey="Beare R" first="Richard" last="Beare">Richard Beare</name><name sortKey="Callisaya, Michele" sort="Callisaya, Michele" uniqKey="Callisaya M" first="Michele" last="Callisaya">Michele Callisaya</name><name sortKey="Moran, Chris" sort="Moran, Chris" uniqKey="Moran C" first="Chris" last="Moran">Chris Moran</name><name sortKey="Phan, Thanh" sort="Phan, Thanh" uniqKey="Phan T" first="Thanh" last="Phan">Thanh Phan</name><name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name></region><name sortKey="Adams, Hieab Hh" sort="Adams, Hieab Hh" uniqKey="Adams H" first="Hieab Hh" last="Adams">Hieab Hh Adams</name><name sortKey="Adams, Hieab Hh" sort="Adams, Hieab Hh" uniqKey="Adams H" first="Hieab Hh" last="Adams">Hieab Hh Adams</name><name sortKey="De Craen, Anton Jm" sort="De Craen, Anton Jm" uniqKey="De Craen A" first="Anton Jm" last="De Craen">Anton Jm De Craen</name><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name><name sortKey="Slagboom, P Eline" sort="Slagboom, P Eline" uniqKey="Slagboom P" first="P Eline" last="Slagboom">P Eline Slagboom</name><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><name sortKey="Van Buchem, Mark" sort="Van Buchem, Mark" uniqKey="Van Buchem M" first="Mark" last="Van Buchem">Mark Van Buchem</name><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><name sortKey="Verhaaren, Benjamin Fj" sort="Verhaaren, Benjamin Fj" uniqKey="Verhaaren B" first="Benjamin Fj" last="Verhaaren">Benjamin Fj Verhaaren</name><name sortKey="Verhaaren, Benjamin Fj" sort="Verhaaren, Benjamin Fj" uniqKey="Verhaaren B" first="Benjamin Fj" last="Verhaaren">Benjamin Fj Verhaaren</name><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W" last="Vernooij">Meike W. Vernooij</name><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W" last="Vernooij">Meike W. Vernooij</name><name sortKey="Westendorp, Rudi Gj" sort="Westendorp, Rudi Gj" uniqKey="Westendorp R" first="Rudi Gj" last="Westendorp">Rudi Gj Westendorp</name></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Wolf, Christiane" sort="Wolf, Christiane" uniqKey="Wolf C" first="Christiane" last="Wolf">Christiane Wolf</name></region><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Chauhan, Ganesh" sort="Chauhan, Ganesh" uniqKey="Chauhan G" first="Ganesh" last="Chauhan">Ganesh Chauhan</name><name sortKey="Chauhan, Ganesh" sort="Chauhan, Ganesh" uniqKey="Chauhan G" first="Ganesh" last="Chauhan">Ganesh Chauhan</name><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stéphanie" last="Debette">Stéphanie Debette</name><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stéphanie" last="Debette">Stéphanie Debette</name><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name><name sortKey="Schilling, Sabrina" sort="Schilling, Sabrina" uniqKey="Schilling S" first="Sabrina" last="Schilling">Sabrina Schilling</name><name sortKey="Schilling, Sabrina" sort="Schilling, Sabrina" uniqKey="Schilling S" first="Sabrina" last="Schilling">Sabrina Schilling</name><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Wolf, Christiane" sort="Wolf, Christiane" uniqKey="Wolf C" first="Christiane" last="Wolf">Christiane Wolf</name></region></country><country name="Irlande (pays)"><noRegion><name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M" last="Buckley">Brendan M. Buckley</name></noRegion></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name></region><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J" last="Stott">David J. Stott</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Lumley, Thomas" sort="Lumley, Thomas" uniqKey="Lumley T" first="Thomas" last="Lumley">Thomas Lumley</name></noRegion></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Westendorp, Rudi Gj" sort="Westendorp, Rudi Gj" uniqKey="Westendorp R" first="Rudi Gj" last="Westendorp">Rudi Gj Westendorp</name></region></country><country name="Canada"><noRegion><name sortKey="Zijdenbos, Alex" sort="Zijdenbos, Alex" uniqKey="Zijdenbos A" first="Alex" last="Zijdenbos">Alex Zijdenbos</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
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Ou
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|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4749149
|texte= White matter lesion progression: A genome-wide search for genetic influences
}}
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